Sex-Specific Neurogenic Deficits and Neurocognitive Disorders in Middle-Aged HIV-1 Tg26 Transgenic Mice.

Raj Putatunda,Yonggang Zhang,Fang Li, Philip Regis Fagan,Huaqing Zhao,Servio H Ramirez,Domenico Praticò,Mary F Barbe,Wenhui Hu

Brain, Behavior, and Immunity（2019）

引用 14|浏览11

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摘要

•Reduced spatial learning ability in female, but not male Tg26(+/−) mice.•Short-term and long-term memory deficits in male Tg26(+/−) mice.•Short-term, but not long-term memory deficits in female Tg26(+/−) mice.•Sex-specific adult neurogenic impairments in Tg26(+/−) mice.

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关键词

HIV-1,HAND,Tg26 mouse,Neurogenesis,Neural stem cells,Differentiation,Fear conditioning,Barnes maze,Biological sex

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