Long-Term Effects Of Androgen Deprivation In A Patient With Spinal And Bulbar Muscular Atrophy - A Case Report With 14 Years Of Follow-Up
INTERNAL MEDICINE(2019)
摘要
Spinal and bulbar muscular atrophy (SBMA) is a progressive hereditary neuromuscular disease caused by the testosterone-dependent accumulation of pathogenic polyglutamine-expanded androgen receptor protein. A 41-year-old man with SBMA received the androgen deprivation agent leuprorelin acetate for 7 years in clinical trials and underwent castration following the trial. Suppression of testosterone levels for 14 years resulted in a slower disease progression, as measured prospectively with quantitative measurements, than the historical control data reported in previous studies. This suggests that long-term androgen deprivation delays disease progression in SBMA.
更多查看译文
关键词
spinal and bulbar muscular atrophy, androgen deprivation, leuprorelin acetate, disease modifying therapies
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要