Multi-Exponential Relaxometry Using $\ell_{{1}}$ -Regularized Iterative NNLS (MERLIN) With Application to Myelin Water Fraction Imaging

A new parameter estimation algorithm, MERLIN, is presented for accurate and robust multiexponential relaxometry using magnetic resonance imaging, a tool that can provide valuable insight into the tissue microstructure of the brain. Multi-exponential relaxometry is used to analyze the myelin water fraction and can help to detect related diseases. However, the underlying problem is ill-conditioned, ...