Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.
Joey L. Methot,Hua Zhou,Sam D. Kattar,Meredeth A. McGowan,Kevin Wilson,Yudith Garcia, Yongi Deng,Michael Altman,Xavier Fradera,Charles Lesburg,Thierry Fischmann,Chaomin Li,Steve Alves,Sanjiv Shah,Rafael Fernandez,Peter Goldenblatt,Armetta Hill,Lynsey Shaffer,Dapeng Chen,Vince Tong,Robbie L. McLeod,Hongshi Yu,Alan Bass, Ray Kemper,Nicholas T. Gatto,Lisa LaFranco-Scheuch,Benjamin Wesley Trotter,Timothy Guzi,Jason D. Katz Journal of Medicinal Chemistry（2019）
Key words
PI3K/AKT pathway
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