No synergistic effect of subtherapeutic doses of donepezil and EVP-6124 in healthy elderly subjects in a scopolamine challenge model.

Anne Catrien Baakman,Ricardo Alvarez-Jimenez, Gordon Loewen,Marieke L de Kam,Karen Broekhuizen,Dana C Hilt,Geert Jan Groeneveld

Alzheimer's & Dementia: Translational Research & Clinical Interventions（2019）

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摘要

This study shows no synergistic effect of subtherapeutic doses of donepezil and EVP-6124 in a scopolamine challenge model in healthy elderly subjects. Dosing of scopolamine and the combination of donepezil and EVP-6124 requires further study.

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关键词

Alpha-7 nicotinic agonist,EVP-6124,Cholinesterase inhibitor,Donepezil,Alzheimer's disease

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