Nine-valent HPV vaccine efficacy against related diseases and definitive therapy: comparison with historic placebo population.

•The 9vHPV vaccine prevents 98% of high-grade cervical dysplasia related to the 9 HPV types covered by the vaccine.•The 9vHPV vaccine prevents 98% of cervical surgeries related to the 9 HPV types covered by the vaccine.•Vaccine did not prevent diseases related to HPV types detected at baseline but reduced diseases related to other HPV types.•While early vaccination in HPV naïve persons is best, sexually active persons may benefit from catch-up vaccination programs.•These data will be important to inform future public health vaccination recommendations.