Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice.

Joonki Kim,Sharmelee Selvaraji,Sung Wook Kang,Wei Thye Lee,Christopher Li-Hsian Chen,Hyungwon Choi,Edward H Koo,Dong-Gyu Jo,Kah Leong Lim,Yun-An Lim,Thiruma V Arumugam

Brain, Behavior, and Immunity（2019）

引用 11|浏览24

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摘要

•P301S mutation leads to transcriptomic changes related to neuroinflammation.•P301S mutation induces transcriptomic changes relating to the aging process.•Prolonged accumulation of hyperphosphorylated tau worsens neuroinflammation.

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关键词

P301S,PS19,Tauopathy,Neuroinflammation,RNA sequencing,Transcriptome

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