Determination of thyroid hormones in human hair with online SPE LC-MS/MS: Analytical protocol and application in study of burnout.

Wei Gao,Marlene Penz,Magdalena Wekenborg,Andreas Walther,Clemens Kirschbaum

Psychoneuroendocrinology（2019）

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摘要

•An online SPE LC–MS/MS method is developed for detection of T3 and T4 in human hair.•A comparison of thyroid hormones concentrations is made between hair and plasma.•Participants with high degree of burnout had significantly higher hair T4 levels and lower T3/T4 ratio.•Hair T4 levels showed a significant positive relationship with MBI-GS score.

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关键词

Thyroid hormones,Human hair,Mass spectrometry,Burnout

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