Astragaloside IV and Ferulic Acid Synergistically Promote Neurite Outgrowth through Nrf2 Activation.

Yini Liang,Yu Zou,Chengu Niu,Yingcai Niu

Mechanisms of Ageing and Development（2019）

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摘要

•FA/AS-IV synergistically promote neurite outgrowth via antioxidant properties.•FA/AS-IV synergistically promotes nuclear translocation of Nrf2.•FA but not AS-IV activates the ERK1/2 upstream of Nrf2.•AS-IV but not FA suppresses Akt/GSK-3β/Fyn pathway.

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关键词

ARE,AS-I,CI,DN,ERK1/2,FA,GCLc,GSK-3β,HO-1,LPO,MAPK,Nrf2,PbAc,ROS

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