Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload.

Ioannis Smyrnias,Stephen P Gray,Darlington O Okonko,Greta Sawyer,Anna Zoccarato,Norman Catibog,Begoña López,Arantxa González,Susana Ravassa,Javier Díez,Ajay M Shah

Journal of the American College of Cardiology（2019）

引用 85|浏览23

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摘要

These results identify the induction of the UPR in the mammalian (including human) heart exposed to pathological stresses. Enhancement of the UPR ameliorates mitochondrial and contractile dysfunction, suggesting that it may serve an important protective role in the stressed heart.

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cardiomyocyte,heart,mitochondria,pressure overload,unfolded protein response

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