Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation.
Molecular medicine (Cambridge, Mass.)(2019)
摘要
These results demonstrate that therapies based on HMGB1 antagonists and the cholinergic anti-inflammatory pathway share a previously unrecognized molecular mechanism of substantial clinical relevance.
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关键词
Cytokine,Endocytosis sepsis,HMGB1,LPS,RAGE
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