Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation.

Manuela Mura,Yee-Ki Lee,Federica Pisano,Monia Ginevrino,Marina Boni,Federica Calabrò,Lia Crotti,Enza Maria Valente,Peter J Schwartz,Hung-Fat Tse,Massimiliano Gnecchi

Stem cell research（2019）

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摘要

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a male carrier of the heterozygous mutation c.1781 G > A p.R594Q on the KCNQ1 gene. hiPSCs, generated using four retroviruses each encoding for OCT4, SOX2, KLF4 and cMYC, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

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