Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

    Long V Pham
    Long V Pham
    Qi Tang
    Qi Tang
    Martin Schou Pedersen
    Martin Schou Pedersen
    Anne Finne Pihl
    Anne Finne Pihl
    Jonathan Filskov
    Jonathan Filskov

    Hepatology (Baltimore, Md.), 2019.

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    Keywords:
    direct acting antiviralsglecaprevirgrazoprevir, voxilaprevirresistance

    Abstract:

    Protease inhibitors (PIs) are important components of treatment regimens for patients with chronic hepatitis C virus (HCV) infection. However, emergence and persistence of antiviral resistance could reduce their efficacy. Thus, defining resistance determinants is highly relevant for efforts to control HCV. Here, we investigated patterns o...More

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