Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

Long V Pham
Long V Pham
Qi Tang
Qi Tang
Martin Schou Pedersen
Martin Schou Pedersen
Anne Finne Pihl
Anne Finne Pihl
Jonathan Filskov
Jonathan Filskov

Hepatology (Baltimore, Md.), 2019.

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Keywords:
direct acting antiviralsglecaprevirgrazoprevir, voxilaprevirresistance

Abstract:

Protease inhibitors (PIs) are important components of treatment regimens for patients with chronic hepatitis C virus (HCV) infection. However, emergence and persistence of antiviral resistance could reduce their efficacy. Thus, defining resistance determinants is highly relevant for efforts to control HCV. Here, we investigated patterns o...More

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