Double-attenuated influenza virus elicits broad protection against challenge viruses with different serotypes in swine.

Svenja Mamerow, Robert Scheffter,Susanne Röhrs,Olga Stech,Ulrike Blohm,Theresa Schwaiger,Charlotte Schröder,Reiner Ulrich,Jan Schinköthe,Martin Beer,Thomas C Mettenleiter,Jürgen Stech

Veterinary Microbiology（2019）

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摘要

•As LAIV, we generated a double-attenuated mutant with an elastase-susceptible HA cleavage site and a shortened NS1.•In vitro, this double-attenuated mutant is strictly elastase-dependent.•Upon homosubtypic challenge, immunized pigs displayed reduced clinical signs and no nasal virus shedding.•Protection against homosubtypic challenge suggests requirement of less frequent updates with recent HA and NA genes.

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关键词

Influenza viruses,Swine influenza,Attenuated live vaccine,LAIV

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