Toxicological assessment of dust from sanding micronized copper-treated lumber in vivo.

Jennifer D Sisler,W Kyle Mandler,Justine Shaffer,Taekhee Lee,Walter G McKinney,Lori A Battelli,Marlene S Orandle,Treye A Thomas,Vincent C Castranova,Chaolong Qi,Dale W Porter,Michael E Andrew,Jeffrey S Fedan,Robert R Mercer,Yong Qian

Journal of Hazardous Materials（2019）

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摘要

•Micronized copper azole (MCA) is a novel treatment for waterproofing lumber.•Our group has established that sanding this material releases cytotoxic particles, including nanoparticles.•We exposed mice to dust from untreated yellow pine, MCA, or copper azole-treated lumber (CA-C) via oropharyngeal aspiration.•Both MCA and CA-C increased inflammation more than UYP exposure, including lavage cytokines and inflammatory cells.•MCA caused more severe inflammatory responses than CA-C at 1 day post-exposure.

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关键词

Wood dust,Pulmonary injury,Micronized copper,In vivo toxicity,Inflammation

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