Impact of Prenatal Arsenate Exposure on Gene Expression in a Pure Population of Migratory Cranial Neural Crest Cells.
Reproductive Toxicology(2019)
摘要
•Isolated pure population of mouse cranial neural crest cells (CNCCs).•Studied the effects of in utero exposure to sodium arsenate on CNCCs.•Reported arsenate-induced alterations in the expression of novel candidate genes.•Identified novel signaling pathways potentially impacted by arsenate exposure.•Identified novel genes & canonical cascades that may contribute to arsenate-induced orofacial defects.
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关键词
Arsenate,Craniofacial development,Embryo,Gene expression profiling,Microarray,Neural crest cells
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