Impact of Prenatal Arsenate Exposure on Gene Expression in a Pure Population of Migratory Cranial Neural Crest Cells.

Reproductive Toxicology(2019)

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摘要
•Isolated pure population of mouse cranial neural crest cells (CNCCs).•Studied the effects of in utero exposure to sodium arsenate on CNCCs.•Reported arsenate-induced alterations in the expression of novel candidate genes.•Identified novel signaling pathways potentially impacted by arsenate exposure.•Identified novel genes & canonical cascades that may contribute to arsenate-induced orofacial defects.
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关键词
Arsenate,Craniofacial development,Embryo,Gene expression profiling,Microarray,Neural crest cells
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