Coating of cobalt chrome substrates with thin films of polar/hydrophobic/ionic polyurethanes: Characterization and interaction with human immunoglobulin G and fibronectin.

•Polar/hydrophobic/ionic polyurethanes (PUs) μm-films are generated on metal.•Organic solvent affects surface structure and chemistry of PUs on cobalt chrome.•Protein adsorption on the PUs films led to a reduced exposure of peptide sequences.•Specific chemistry of the PUs is critical for biomaterial-protein interactions.