Symptomatic HIV CNS viral escape among patients on effective cART.

Abi Manesh, Rohit Barnabas,Sunithi Mani,Rajiv Karthik,O C Abraham,Geeta Chacko,Rajesh Kannangai,George M Varghese

International Journal of Infectious Diseases（2019）

引用 16|浏览12

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摘要

•Symptomatic HIV CNS viral escape presents as a global cerebral syndrome in treatment experienced patients.•Atazanavir and Tenofovir may be associated with CNS viral escape due to poor CNS penetration.•CNS viral escape produces a CD8 predominant inflammation in the CNS.•Appropriate change of cART improves symptoms in most patients.

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关键词

Symptomatic CNS escape,HIV viral escape CNS,Cerebral penetration effectiveness score,Cognitive decline HIV

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