Procyanidin protects against 6-hydroxydopamine-induced dopaminergic neuron damage via the regulation of the PI3K/Akt signalling pathway.

Ying Zhang,Nanqu Huang,Mingji Chen,Hai Jin,Jing Nie,Jingshan Shi,Feng Jin

Biomedicine & Pharmacotherapy（2019）

引用 15|浏览11

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摘要

•Procyanidin protects against 6-OHDA-induced neurotoxicity in rats and PC12 cells.•Procyanidin reduce oxidative stress and improve mitochondrial dysfunction.•Procyanidin protects against 6-OHDA-induced neurotoxicity via activation of the PI3K/Akt signalling pathway.

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关键词

6-OHDA,Akt,CCCP,DA,GPCRs,LDH,MMP,OFT,PBS,PC,PD,PI3K,RIPA,ROS,SN,SNc,SOD,TH

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