Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications

Tse-Shun Huang
Tse-Shun Huang
Shuai Li
Shuai Li
Hsiao-Chin Hong
Hsiao-Chin Hong
Xin Zhou
Xin Zhou
Shu-Han Su
Shu-Han Su
Jiao Zhang
Jiao Zhang
Wei-Ting Wang
Wei-Ting Wang
Jian Kang
Jian Kang

Arteriosclerosis, thrombosis, and vascular biology, Volume 39, Issue 5, 2019, Pages 902-914.

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Keywords:
endothelial cellsgenomehistonesnitric oxidepolymerase chain reaction

Abstract:

Objective- The topographical distribution of atherosclerosis in vasculature underscores the importance of shear stress in regulating endothelium. With a systems approach integrating sequencing data, the current study aims to explore the link between shear stress-regulated master transcription factor and its regulation of endothelial cell ...More

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