Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice.

Daniel Jahn,Donata Dorbath,Anne-Kristin Schilling, Lisa Gildein,Chantal Meier,Raphael N Vuille-Dit-Bille,Johannes Schmitt,Daniel Kraus,James C Fleet,Heike M Hermanns,Andreas Geier

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2019）

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摘要

•Vdr−/− mice are resistant to HFD-induced obesity and liver steatosis.•Gut-specific re-expression of VDR in Vdr−/− mice partially reverses this effect.•Intestinal VDR represses mRNA expression of the endocrine LPL inhibitor Angptl4.•Thereby, intestinal VDR regulates lipid metabolism in extra-intestinal organs.•Intestinal VDR is an interesting pharmacological target in obesity and NAFLD.

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关键词

Angptl4,CLS,eWAT,HFD,LFD,LPL,NAFLD,NEFA,PPAR,PTH,T2DM,TG,VDR

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