A computationally designed H5 antigen shows immunological breadth of coverage and protects against drifting avian strains.

Ted M Ross,Joshua DiNapoli,Maryann Giel-Moloney,Chalise E Bloom,Kateri Bertran,Charles Balzli,Tod Strugnell,Mariana Sá E Silva,Teshome Mebatsion,Michel Bublot,David E Swayne,Harry Kleanthous

Vaccine（2019）

引用 19|浏览24

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摘要

•Vaccination is the most effective strategy in pre-pandemic preparedness.•Engineered HA immunogens can elicit protective immunity against drift variants.•A computational design strategy could reduce frequent vaccine updates.

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关键词

Influenza,H5N1,Universal vaccine,Chickens,COBRA,Pre-pandemic

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