FXR agonism protects against liver injury in a rat model of intestinal failure-associated liver disease.

Kiran V K Koelfat,Ruben G J Visschers,Caroline M J M Hodin,D Rudi de Waart,Wim G van Gemert,Jack P M Cleutjens,Marion J Gijbels,Ronit Shiri-Sverdlov,Rajeshwar P Mookerjee,Kaatje Lenaerts,Frank G Schaap,Olde Damink Steven W M

Journal of clinical and translational research（2018）

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摘要

This study demonstrates that chronic loss of bile causes liver injury in rats. Abro-gated recycling of bile salts impairing of enterohepatic bile salt/FXR signaling underlies these pathological changes, as administration of FXR agonist INT747 prevents biliary drainage-induced liver damage. Phar-macological activation of FXR might be a therapeutic strategy to treat disorders accompanied by a per-turbed enterohepatic circulation such as intestinal failure-associated liver disease.

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关键词

FXR,bile salt signaling,enterocutaneous fistula,enterohepatic cycle,intestinal failure,liver disease

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