Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines As TARP Γ-8 Selective AMPAR Negative Modulators.

Brad M. Sayall,Dongpei Wu,Devin M. Swanson,Mark Seierstad,Nyantsz Wu, Jorge Vives Martinez, Beatriz Garcia Olmos,Brian Lord,Kevin Coe,Tatiana Koudriakova,Timothy W. Lovenberg,Nicholas I. Carruthers,Michael P. Maher,Michael K. Ameriks

ACS Medicinal Chemistry Letters（2018）

引用 15|浏览3

关键词

AMPA,a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid,AMPA,TARP gamma-8,transmembrane AMPA receptor regulatory protein,auxiliary subunit,glutamate,hippocampus,epilepsy,glutathione,autoradiography

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