Neuroprotective effects of acetyl-L-carnitine (ALC) in a chronic MPTP-induced Parkinson's disease mouse model: Endothelial and microglial effects.

Susan Burks,James Raymick,Bonnie Robinson,Joseph Hanig,Sumit Sarkar

Neuroscience Letters（2019）

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摘要

•First instance of ALC preventing glial activation in MPTP animals.•First instance of ALC preventing Glut-1, OCL, and ZO-1 loss in MPTP animals.•ALC preventing loss of TH, DAT, and DA confirms 6-OHDA and MPTP model findings.•ALC preventing astrocytic response confirms 6-OHDA model findings.

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关键词

DA,SNc,CPu,ALC,PROB,MPTP,MPTPp,DAT,TH,Glut-1,PD,HPLC,GFAP,ZO-1,OCL

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