Activity of Combinations of Zinc Chelators with Amphotericin B and Posaconazole Against Six Mucorales Species.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY(2019)
摘要
Mucormycosis is an emerging disease with high mortality rates. Few antifungal drugs are active against Mucorales. Considering the low efficacy of monotherapy, combination-therapy strategies have been described. It is known that fungi are susceptible to zinc deprivation, so we tested the in vitro effect of the zinc chelators clioquinol, phenanthroline, and N,N,N',N'-tetrakis(2-pyridylmethyl) ethane-1,2-diamine combined with amphotericin B or posaconazole against 25 strains of Mucorales. Clioquinol-posaconazole was the most active combination, although results were strain dependent.
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关键词
Mucorales,zinc chelators,antifungal susceptibility testing,posaconazole
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