IKKβ targeting reduces KRAS-induced lung cancer angiogenesis in vitro and in vivo: A potential anti-angiogenic therapeutic target.

Tatiana Correa Carneiro-Lobo, Luiza Coimbra Scalabrini, Leila da Silva Magalhães,Laura B Cardeal,Felipe Silva Rodrigues,Edmilson Ozorio Dos Santos,Albert S Baldwin,Elena Levantini,Ricardo J Giordano,Daniela Sanchez Bassères

Lung Cancer（2019）

引用 11|浏览16

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摘要

•IKKβ promotes KRAS-induced proangiogenic IL-8 and VEGF expression and secretion.•IKKβ promotes KRAS-induced endothelial cell migration, invasion and tube formation.•IKKβ targeting reduces KRAS-mutant lung tumor growth and angiogenesis.•IKKβ targeting reduces pathological angiogenesis in a cancer-independent model.

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关键词

Angiogenesis,KRAS,IKKβ,Lung cancer,IL-8,VEGF,Therapeutic target

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