MiR-145 mediates cell morphology-regulated mesenchymal stem cell differentiation to smooth muscle cells

Josh Wei
Josh Wei
Satenick Thorossian
Satenick Thorossian
Katherine Nguyen
Katherine Nguyen
Clarissa Hoffman
Clarissa Hoffman
Yi-Shuan Julie Li
Yi-Shuan Julie Li

Biomaterials, Volume 204, 2019, Pages 59-69.

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Keywords:
Cell shape modulationMesenchymal stem cellSmooth muscle cellmiR-145

Abstract:

The use of biochemical signaling to derive smooth muscle cells (SMCs) from mesenchymal stem cells (MSCs) has been explored, but the induction of a fully functional SMC phenotype remains to be a major challenge. Cell morphology has been shown to regulate MSC differentiation into various lineages, including SMCs. We engineered substrates wi...More

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