MiR-145 mediates cell morphology-regulated mesenchymal stem cell differentiation to smooth muscle cells
Biomaterials, Volume 204, 2019, Pages 59-69.
Cell shape modulationMesenchymal stem cellSmooth muscle cellmiR-145
The use of biochemical signaling to derive smooth muscle cells (SMCs) from mesenchymal stem cells (MSCs) has been explored, but the induction of a fully functional SMC phenotype remains to be a major challenge. Cell morphology has been shown to regulate MSC differentiation into various lineages, including SMCs. We engineered substrates wi...More
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