Syntenin regulates Hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes.
Journal of Hepatology(2019)
摘要
•Syntenin is a key determinant of the efficiency of E2-coated exosome production.•E2-coated exosome biogenesis is independent of HCV infectious lipo-viral-particle production.•Robust E2-coated exosome production assists HCV infection in the presence of neutralizing antibody.
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关键词
HCV,Syntenin,Exosomes,Neutralizing antibodies,Lipo-viro-particles,Virions
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