Contemporary trend of reduced-dose non-vitamin K anticoagulants in Japanese patients with atrial fibrillation: A cross-sectional analysis of a multicenter outpatient registry.

•In Japan, 66.8% atrial fibrillation patients were prescribed non-vitamin K oral anticoagulants (NOACs), well beyond the global average.•About 15% of patients received NOAC with a non-standardized dose reduction (NSDR).•Patients with CHA2DS2-VASc score ≥2 had the highest proportion of NSDRs.•The physician's apprehension for bleeding should be balanced with stroke risk.