Atypical Symptoms and Results of Non-Invasive Tests Do Not Explain Poor Diagnostic Yield of Invasive Angiography in Women Suspected of Obstructive Coronary Artery Disease

Background: Angina pectoris is the most common symptom of coronary artery disease (CAD) among women but large studies have indicated low diagnostic yield of invasive coronary angiography (ICA). It is well accepted that women have more atypical symptoms and that some tests perform less well in women. Purpose: To examine whether symptoms and non-invasive test result (NIT) are less predictive of obstructive CAD in women compared to men in a large city hospital. Methods: Patients referred for assessment of stable CAD in 2012-2014 in a single center were included. Information on symptoms, risk factors, results of NIT and ICA was gathered from registries and patient records. Ability of symptoms and NIT result to predict obstructive CAD in men and women was compared in multiple adjusted logistic regression models by testing for statistical interaction. Results: A total of 2763 patients were included, 1462 (53%) women. Women were older (59.1 vs 56.4 years, pu003c0.0001), more likely to have non-anginal chest pain and...