Analysis Of Delayed Reconstruction And Tumor Relapse In Breast Cancer.

e23003 Background: Some studies show that the surgery be associated with the increase of cell growth stimulating factors and angiogenesis of tumor dormancy. Furthermore clinical observations have found as the highest percentage of recurrence in breast cancer arise in the nearest time to primary tumor surgery, supporting the hypothesis of the stimulating effect of surgery on tumour dormancy cells. However it is unknown whether other surgery as breast reconstruction influences equally in the recurrence. Methods: 200 delayed breast reconstructions were performed in one or two surgical times using different techniques, in patients diagnosed with breast carcinoma. The clinical, histo-pathological, surgical and recurrence pattern were analyzed. Results: A 92% had T1-T2 tumors, 66% were N0, 87% had IDC, 60% were G1-G2, 65% were PgR / ER-positive and 55% underwent surgical reconstruction technique in two times vs. 44% who did so in one time. The 25% (50/200) of the patients had relapsed. They displayed significant differences with those known prognostic factors associated with relapse as tumor size, lymph node involvement, histological grade and hormone receptor status. Of patients with relapsed, 70% had been reconstructed in two times and 30% in one surgical time. Statistically significant difference between the type of reconstruction and tumor relapse were found. No significant differences were found between times since reconstruction to relapse, according to the type of reconstruction. Taking into account the time of relapse, 52% occurred in the 24 months following the reconstruction, 18% between 25-50 months post-reconstruction, 16% between 50-100 months post-reconstruction and 14% above 101 months. Conclusions: In our series, delayed breast reconstruction in two times is associated with increased tumour recurrence. There are no differences in time to recurrence according to the technique used, although there are a greater number of relapses in the two years after reconstruction. These findings support the hypothesis of reconstructive surgical stimulus, which through the modification of the homeostasis of tumour dormancy cells, could modify the pattern of tumour relapse.