A Novel Next-Generation Sequencing Approach without Donor-Derived Material for Acute Rejection and Infection Monitoring in Solid Organ Transplantation

Liuhong Zeng
Liuhong Zeng
Chunting Zheng
Chunting Zheng
Qing Yang
Qing Yang
Jibin Zhang
Jibin Zhang
Qiuhua Deng
Qiuhua Deng
Yongping Lin
Yongping Lin
Danxia Huang
Danxia Huang
Liping Liu
Liping Liu

Journal of Cancer Therapy, pp. 623-638, 2018.

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Abstract:

Background: Donor-derived cell free DNA (ddcfDNA) has been reported as a universal noninvasive biomarker for rejection monitoringin heart, kidney, liver, and lung transplantation. Current approaches based on next-generationsequencing for quantification of ddcf DNA, although promising, may be restrictedby the requirement for donor material...More

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