A Novel Next-Generation Sequencing Approach without Donor-Derived Material for Acute Rejection and Infection Monitoring in Solid Organ Transplantation

Background: Donor-derived cell free DNA (ddcfDNA) has been reported as a universal noninvasive biomarker for rejection monitoringin heart, kidney, liver, and lung transplantation. Current approaches based on next-generationsequencing for quantification of ddcf DNA, although promising, may be restrictedby the requirement for donor material...More