Blocking PD1/PDL1 Interactions Together with MLN4924 Therapy is a Potential Strategy for Glioma Treatment.

Natalia Filippova,Xiuhua Yang, Zixiao An,Louis B Nabors,Larisa Pereboeva

Journal of cancer science & therapy（2018）

引用 20|浏览13

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摘要

We conclude that i) PDL1 up-regulation in gliomas and the glioma microenvironment is an important chemotherapeutic target; ii) MLN4924 therapy, combined with a blockage of the PD1/PDL1 pathway, should be considered as a potential strategy for glioma treatment.

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关键词

Brain tumour,Cancer therapy,Gliomas,HIF,Immune checkpoint,MLN4924,PDL1

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