A parallel unidirectional coupled DEM-PBM model for the efficient simulation of computationally intensive particulate process systems.

•A new framework for a unidirectional multi-scale model of wet granulation.•A multi-dimensional Population Balance Model is developed using mechanistic kernel.•Population Balance Model is parallelized to address the computational complexity requirements.•Results demonstrate scaling of DEM and PBM in multiple cores.•The methodology is implemented to high shear wet granulation process.