PET Radioligands for imaging of the PDE10A in human: current status

Neuroscience Letters(2019)

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摘要
•Evaluation of 6 PET radioligands for PDE10 A imaging in human has been summarised.•Suitable carbon-11 and fluorine-18 PET radioligands are available for in vivo quantification of the PDE10 A in human.•PDE10 A PET imaging in patients may help define therapeutic indications of PDE10 A inhibitors.•PDE10 A PET imaging supports the enzyme involvement in neurodegenerative disorders.
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关键词
PET imaging,PDE10A,Radiopharmaceuticals,Molecular imaging,Neuropsychiatry,Neurodegenerative
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