Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis.

Xiaojuan He,Jin Liu,Chao Liang,Shaikh Atik Badshah,Kang Zheng,Lei Dang,Baosheng Guo,Defang Li,Cheng Lu,Qingqing Guo,Danping Fan,Yanqin Bian,Hui Feng,Lianbo Xiao,Xiaohua Pan,Cheng Xiao,BaoTing Zhang,Ge Zhang,Aiping Lu

EBioMedicine（2019）

引用 13|浏览82

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摘要

These data strongly suggest that the highly expressed PLEKHO1 in osteoblasts contributes to joint inflammation in RA. Targeting osteoblastic PLEKHO1 may exert dual therapeutic action of alleviating joint inflammation and promoting bone formation in RA.

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关键词

Osteoblast,PLEKHO1,Rheumatoid arthritis,Inflammation,Bone formation

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