HDAC11 regulates interleukin-13 expression in CD4+ T cells in the heart.

Li Yuan,Xiao Chen,Liang Cheng,Man Rao,Kai Chen,Ningning Zhang,Jian Meng,Mengmeng Li,Li-Tao Yang,Ping-Chang Yang,Xin Wang,Jiangping Song

Journal of Molecular and Cellular Cardiology（2018）

引用 19|浏览8

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摘要

•Th2-biased inflammation was observed in the hearts with myocarditis (MCD).•CD4+ T cells of the MCD heart tissue had lower levels of HDAC11.•HDAC11 restricted the expression of IL-13.•Reconstitution of HDAC11 in the MCD CD4+ T cells reduced the expression of IL-13.

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关键词

Inflammation,Heart,Th2,Myocarditis,HDAC11

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