V260E Is a Frequent Cause of Steroid-Resistant Nephrotic Syndrome in Black South African Children.

Kareshma Asharam,Rajendra Bhimma,Victor A David,Hoosen M Coovadia, Wenkosi P Qulu,Thajasvarie Naicker,Christopher E Gillies,Virginia Vega-Warner,Randall C Johnson,Sophie Limou,Jeffrey B Kopp, Mathew Sampson,George W Nelson,Cheryl A Winkler

Kidney International Reports（2018）

引用 17|浏览34

暂无评分

摘要

260E/E was present in one-third of black FSGS patients, was absent in black controls and Indian patients, and affected patients were unresponsive to therapy. Genotyping V260E in black children from South Africa with NS will identify a substantial group with SR-FSGS, potentially sparing these children biopsy and ineffective steroid treatment.

查看译文

关键词

APOL1,CD2AP,FSGS,nephrotic syndrome,NPHS2,steroid resistance

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要