Association of Per3 length polymorphism with susceptibility of Alzheimer disease (AD) in Chinese population

Objectives: The association of Per3 length polymorphism with susceptibility of Alzheimer Disease (AD) was examined in the present study. Methods: This study was constructed using the case-control method and investigated the association of Per3 length polymorphism with susceptibility of AD. Genotypes of APOE and Per3 length were determined by a PCR restriction fragment length polymorphism detection method. Results: In this study, we gathered 130 unrelated AD patients and 188 controls in performing an analysis the association of Per3 length polymorphism with susceptibility of AD. In the whole sample or APOE epsilon 4 non-carriers, an increased prevalence of five repeat homozygotes of Per3 length in AD patients had significant higher than that in controls (in the whole sample: chi(2) = 7.261,= 0.0176; in APOE epsilon 4 non-carriers: chi(2) = 6.086, p = 0.030). And, among APOE epsilon 4 carriers, an increased prevalence of five repeat homozygotes of Per3 length in AD patients had also significant higher than that in controls (chi(2) = 3.893, p = 0.0319). Conclusions: Among APOE epsilon 4 non-carriers, five repeat homozygotes of Per3 length was associated with a high susceptibility of AD among APOE epsilon 4 carriers and non-carriers.