Recent progress in therapeutic antibodies for cancer immunotherapy
Current Opinion in Chemical Biology(2018)
摘要
•There is a heavy focus of clinical cancer research efforts on cancer immunotherapy.•Treatment with checkpoint inhibitors has shown to improve standard of care.•Immune escape mechanisms may involve different immune phenotypes.•Biomarkers include PD-L1 expression, gene signatures, and tumor mutation burden.•New combinations and bi-specific antibody technologies are being developed.
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