Acetylenic fatty acids from Porcelia macrocarpa (Annonaceae) against trypomastigotes of Trypanosoma cruzi: Effect of octadec-9-ynoic acid in plasma membrane electric potential.

•Acetylene fatty acids 1–4 were isolated from flowers of Porcelia macrocarpa.•Compounds 1–3 displayed activity against T. cruzi and reduced cytotoxicity.•Compound 1 alters plasma membrane permeability and mitochondrial dysfunction.