Adenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders.

Ted J Warren,Timothy A Simeone,D David Smith,Ryan Grove,Jiri Adamec,Kaeli K Samson, Harrison M Roundtree,Deepak Madhavan,Kristina A Simeone

Neurobiology of Disease（2018）

引用 8|浏览28

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摘要

•Energy charge storage in adenine nucleotides is decreased in Kv1.1 KO brain.•Adenosine regionally differs in a model of epilepsy with sleep disorders.•Adenosine is decreased in Kv1.1 KO seizure-genic hippocampus.•Adenosine is increased in sleep-regulating Kv1.1 KO lateral hypothalamus.

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关键词

Mitochondria,Kv1.1 knockout,Cerebral cortex,Hippocampus,Lateral hypothalamus

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