Memory CD8+ T cells support the maintenance of hematopoietic stem cells in the bone marrow.

Sulima Geerman,Giso Brasser,Sudeep Bhushal,Fiamma Salerno,Natasja A Kragten,Mark Hoogenboezem,Gerald de Haan,Monika C Wolkers,María Fernanda Pascutti,Martijn A Nolte

HAEMATOLOGICA（2018）

引用 16|浏览18

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摘要

Following viral infections, considerable numbers of virus-specific memory T cells accumulate in the bone marrow (BM).[1][1] This organ is rich in interleukin-15, which is required for the long-term maintenance of memory T cells.[2][2] Whether this is driven by local homeostatic proliferation or by

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关键词

Bone marrow,CD8 T cells,Hematopoiesis,Hematopoietic Stem Cell,Lymphocytes

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