A simple clinical score to promote and enhance ferroportin disease screening

•Metabolic syndrome-related iron metabolism disorders are common and difficult to distinguish from ferroportin disease.•Ferroportin disease prevalence is higher than initially thought.•The lack of definite criteria for genetic testing and its limited availability hinders proficient ferroportin disease screening.•A simple score, based on clinical features with a definite cut-off, can efficiently rule out ferroportin disease or prompt genetic testing.