A novel natural surface-enhanced Raman spectroscopy (SERS) substrate based on graphene oxide-Ag nanoparticles-Mytilus coruscus hybrid system

•The natural SERS substrate based on the GO-AgNPs-M.c. hybrids was fabricated with a simply facile and inexpensive approach.•The SERS substrate achieves highly sensitive SERRS signals with a minimum detectable concentration for R6G as low as 10−14 M.•The SERS substrate obtains the excellent reproducibility (RSD = 6.6%) and the well antioxidant stability with the assist of GO.•The natural SERS substrate shows the immerse potential for the practical detections of MG and MB in biochemical fields.