Anti-HBV Response to Toll-Like Receptor 7 Agonist GS-9620 is Associated with Intrahepatic Aggregates of T Cells and B Cells.

Li Li,Vivian Barry,Stephane Daffis,Congrong Niu,Erik Huntzicker,Dorothy M French,Igor Mikaelian,Robert E Lanford,William E Delaney,Simon P Fletcher

Journal of Hepatology（2018）

引用 44|浏览26

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摘要

•GS-9620 treatment induced the expression of genes associated with HBV clearance.•GS-9620 treatment transiently induced intrahepatic lymphoid aggregates.•The aggregates were not fully differentiated tertiary lymphoid structures.•Intrahepatic NK cell number did not change during GS-9620 treatment.

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关键词

TLR7,Hepatitis B virus,Immunomodulation,Chimpanzee animal model,CD8 T cell,B cell,NK cell,Interferon-alpha,Interferon-stimulated gene,Lymphocyte aggregate,Tertiary lymphoid structure

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