Direct medical costs and its predictors in EMAR-II cohort.

Abstract Objective To analyze the resource utilization in rheumatoid arthritis (RA) patients and predictive factors in and patients treated with biological drugs and biologic-naive. Methods A cross-sectional study was performed in a sample including all regions and hospitals throughout the country. Sociodemographic data, disease activity parameters and treatment data were obtained. Resource utilization for two years of study was recorded and we made costs imputation. Correlation analyzes were performed on all RA patients and those treated with biological and biological naive, to estimate the differences in resource utilization. Factors associated with increased resources utilization (costs) attending to treatment was analyzed by linear regression models. Results We included 1.095 RA patients, 26% male, mean age of 62 ± 14 years. Mean of direct medical costs per patient was €24,291 ± €45,382. Excluding biological drugs, the average cost per patient was €3742 ± €3711. After adjustment, factors associated with direct medical costs for all RA patients were biologic drugs ( P  = .02) and disease activity ( P  = .004). In the biologic-naive group, the predictor of direct medical costs was comorbidity ( P P  = .04), age ( P  = .02) and disease activity ( P  = .007). Conclusion Our data show a remarkable economic impact of RA. It is important to identify and estimate the economic impact of the disease, compare data from other geographic samples and to develop improvement strategies to reduce these costs and increase the quality of care.