Effect of cerebral oxygen saturation on postoperative nausea and vomiting in female laparoscopic surgery patients

Background: The purpose of this study was to investigate effect of cerebral oxygen saturation (SCTO2) on postoperative nausea and vomiting (PONV) in female patients who underwent laparoscopic surgery. Methods: This study included 90 female patients who underwent laparoscopic surgery (60 cases of gynecological operations and 30 cases of gallbladder operations). All patients were allocated into 3 groups of 30 patients each: group A (gynecological laparoscopic surgery), group B (gynecological laparoscopic surgery with mannitol treatment) and group C (laparoscopic cholecystectomy surgery). Perioperative SCTO2, mean blood flow velocity of vertebral artery (VM), vascular resistance index of vertebral artery (RI), and PONV (within 48 hours after surgery) were investigated. Results: No differences in age, body weight, operation time, and hemoglobin levels were observed among the patients (P>.05). The SCTO2 values for groups B and C were lower than those for group A in both brain hemispheres at T-4 and T-5 (P<.05). The VM was higher in group B than in groups A and C at T-3 (P<.05), but differences in VM were not observed between groups B and C at T-4 or T-5. However, the VM of group A was still lower than the other groups (P<.05), and no difference in VM was observed among the 3 groups at T-6 (P>.05). The RI was higher in group C than in groups A and B at T-4 (P<.05). The incidence of PONV within 48 hours after surgery was significantly higher in group A than in the other 2 groups (P<.05). Conclusion: Strategies that maintain normal SCTO2 may reduce the incidence of PONV in female patients who underwent laparoscopy surgery by reducing perioperative intracranial pressure.