Multimodal Non-linear Optical Imaging for Sensitive Detection of Multiple Pharmaceutical Solid-State Forms and Surface Transformations

Dunja Novakovic
Dunja Novakovic
Tatu Rojalin
Tatu Rojalin
Sara J Fraser-Miller
Sara J Fraser-Miller

ANALYTICAL CHEMISTRY, pp. 11460-11467, 2017.

Cited by: 1|Views3
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Abstract:

Two nonlinear imaging modalities, coherent anti-Stokes Raman scattering (CARS) and sum-frequency generation (SFG), were successfully combined for sensitive multimodal imaging of multiple solid-state forms and their changes on drug tablet surfaces. Two imaging approaches were used and compared: (i) hyperspectral CARS combined with principa...More

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